Silica Nanoparticles Mediated

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Apoptosis induction by silica nanoparticles mediated

Apoptosis Induction By Silica Nanoparticles Mediated

Our data demonstrated that silica nanoparticles induced apoptosis in human liver cells, which is ROS mediated and regulated through p53, bax/bcl-2 and caspase pathways. This study suggests that toxicity mechanisms of silica nanoparticles should be further investigated at in vivo level.

Functional Silica NanoparticleMediated

Functional Silica Nanoparticlemediated

Functional Silica Nanoparticle-Mediated Neuronal Membrane Sealing Following Traumatic Spinal Cord Injury Youngnam Cho,1 Riyi Shi,1,2 Albena Ivanisevic,2,3 and Richard Ben Borgens1,2* 1Center for Paralysis Research, School of Veterinary Medicine, Purdue University, West Lafayette, Indiana 2Weldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana

Silica nanoparticles mediated neuronal cell death in

Silica Nanoparticles Mediated Neuronal Cell Death In

Oct 22, 2014 Silica nanoparticles mediated neuronal cell death in corpus striatum of rat brain implication of mitochondrial, endoplasmic reticulum and oxidative stress. Arshiya Parveen 1, Syed Husain Mustafa Rizvi 1, Farzana Mahdi 2, Sandeep Tripathi 3, Iqbal Ahmad 4, Rajendra K. Shukla 5, Vinay K. Khanna 5, Ranjana Singh 1, Devendra K. Patel 6 Abbas Ali ...

DualResponsive Mesoporous Silica Nanoparticles Mediated

Dualresponsive Mesoporous Silica Nanoparticles Mediated

Sep 27, 2016 The combination of chemotherapy and gene therapy could induce the enhanced therapeutic efficacy in the cancer therapy. To achieve this goal, a new mesoporous silica nanoparticles (MSNs)-based codelivery system was developed for targeted simultaneous delivery of doxorubicin (DOX) and Bcl-2 small interfering RNA (siRNA) into breast cancer cells.

Shapecontrolled magnetic mesoporous silica nanoparticles

Shapecontrolled Magnetic Mesoporous Silica Nanoparticles

Shape-controlled magnetic mesoporous silica nanoparticles for magnetically-mediated suicide gene therapy of hepatocellular carcinoma Biomaterials . 2018 Feb154147-157. doi 10.1016/j.biomaterials.2017.10.047.

Signaling Pathways Regulated by Silica Nanoparticles

Signaling Pathways Regulated By Silica Nanoparticles

Mar 05, 2021 Smaller nanoparticles at larger doses have consistently shown elevated cytotoxicity across multiple different metabolic and survival assays, and despite the use of different cell types, MAPK and TNF-mediated signaling pathways were found to be consistently upregulated in response to silica nanoparticle exposure.

NitroxideMediated Polymerizations from Silica

Nitroxidemediated Polymerizations From Silica

Sep 23, 2003 Nitroxide-mediated stable free radical polymerization of styrene was performed from 13 nm diameter silica nanoparticles in two steps. First, an alkoxyamine, based on N-tert-butyl-N-(1-diethylphosphono-2,2-dimethylpropyl) nitroxide (DEPN) carrying a terminal triethoxysilyl functional group was synthesized and covalently attached onto silica. Polystyrene chains with controlled molecular

Capping Silica Nanoparticles with TryptophanMediated

Capping Silica Nanoparticles With Tryptophanmediated

Apr 16, 2019 Mesoporous silica nanoparticles are capped with tryptophan-mediated cucurbit8uril complex with Fe 3 O 4 to minimize the premature drug leakage while being able to deliver the payload on demand at the target tissue.

Silica Nanoparticles Enhance Disease Resistance in

Silica Nanoparticles Enhance Disease Resistance In

Mar 01, 2021 Silica nanoparticles (SiO 2-NPs) induce disease resistance based on salicylic acid dependent pathway. Experiments in Arabidopsis wild type Col-0 and salicylic acid-deficient mutant sid2. CFU Colony-forming units. dpi days post inoculation with virulent Pseudomonas syringae. The bacteria in leaves were quantified 0 and 3 dpi. a A.

Frontiers Silica Nanoparticles as a Probable Anti

Frontiers Silica Nanoparticles As A Probable Anti

4 hours ago However, uses of nanosized materials in agronomy are restricted by the cytotoxicity and genotoxicity they inflict upon the plants and their consumers. In this regard, impacts of silica nanoparticles (SiNPs) on plant physiology, which ranged from positive to negative effects, have been studied (Le et al., 2014 Suriyaprabha et al., 2014).

Mesoporous Silica Nanoparticles Capped with Disulfide

Mesoporous Silica Nanoparticles Capped With Disulfide

Hybrid mesoporous silica nanoparticles (MSNs), which were synthesized using the co-condensation method and engineered with unique redox-responsive gatekeepers, were developed for studying the glutathione-mediated controlled release. These hybrid nanoparticles constitute a mesoporous silica core that can accommodate the guests (i.e., drug, dye) and the PEG shell that can be connected with

Manganese oxidebased multifunctionalized mesoporous

Manganese Oxidebased Multifunctionalized Mesoporous

Oct 01, 2012 The MnOx decorated hollow mesoporous silica nanoparticles (HMSNs) templated by hexadecyltrimethylammonium bromide (C 16 TAB) were fabricated using silica NPs as the hard template combined with a structural difference-based selective etching process , , , , followed by MnOx integration via an in-situ redox reaction between MnO 4 and C 16 TAB molecules . ...

Confined growth of ZIF8 in dendritic mesoporous

Confined Growth Of Zif8 In Dendritic Mesoporous

Notably, silica nanoparticles with controllable morphology, specifically dendritic mesoporous silica/organosilica nanoparticles with large pore sizes ... RNase was selected to investigate the impact of enzyme treatment on nanoparticles and lipofectamine-mediated mRNA transfection in RAW264.7 cells. Flow cytometry was used to quantitatively ...

Silica nanoparticles induce lung inflammation in mice via

Silica Nanoparticles Induce Lung Inflammation In Mice Via

Jun 08, 2020 While amorphous silica is generally considered safe by the U.S. Federal Drug Administration , there is accumulating evidence suggesting the toxicity of amorphous silica nanoparticles 49,50,51, since Song et al firstly reported that lung toxicity might be induced by long-term exposure to nanoparticles in 2009 . Thus, effective protective ...

Mesoporous silica nanoparticlemediated intracellular cre

Mesoporous Silica Nanoparticlemediated Intracellular Cre

This may be of particular interest for genome editing, because it can avoid DNA (transgene) integration into the genome and generate precisely modified nontransgenic plants. In this work, we explore direct protein delivery to plant cells using mesoporous silica nanoparticles (MSNs) as carriers to deliver Cre recombinase protein into maize (Zea mays) cells.

Silica nanoparticles induce JNKmediated inflammation and

Silica Nanoparticles Induce Jnkmediated Inflammation And

Silica nanoparticles induce JNK-mediated inflammation and myocardial contractile dysfunction. Increasing environmental exposure to silica nanoparticles (SiNPs) and limited cardiotoxicity studies posed a challenge for the safety evaluation and management of these materials.

Functional Silica NanoparticleMediated

Functional Silica Nanoparticlemediated

Functional Silica Nanoparticle-Mediated Neuronal Membrane Sealing Following Traumatic Spinal Cord Injury. Youngnam Cho,1Riyi Shi,1,2Albena Ivanisevic,2,3and Richard Ben Borgens1,2*. 1Center for Paralysis Research, School of Veterinary Medicine, Purdue University, West Lafayette, Indiana. 2Weldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana.

Chitosan mediated 5Fluorouracil functionalized silica

Chitosan Mediated 5fluorouracil Functionalized Silica

Chitosan mediated 5-Fluorouracil functionalized silica nanoparticle from rice husk for anticancer activity. Herein, we have reported a cost-effective method of synthesizing highly efficient silica nanomaterial from rice husks for its application as a chemotherapeutic agent. Silica particle with two different sizes 20 nm and 40 nm were achieved from silica precursor obtained from rice husk. 5

DualResponsive Mesoporous Silica Nanoparticles Mediated

Dualresponsive Mesoporous Silica Nanoparticles Mediated

Sep 27, 2016 To achieve this goal, a new mesoporous silica nanoparticles (MSNs)-based codelivery system was developed for targeted simultaneous delivery of doxorubicin (DOX) and Bcl-2 small interfering RNA (siRNA) into breast cancer cells.

Silica nanoparticles induce JNKmediated inflammation and

Silica Nanoparticles Induce Jnkmediated Inflammation And

Jun 05, 2020 Silica nanoparticles induce JNK-mediated inflammation and myocardial contractile dysfunction 1. Introduction. Silica nanoparticles (SiNPs), possess physicochemical properties such as large specific surface area... 2. Materials and methods.

Silica Nanoparticles Suppress FibronectinMediated

Silica Nanoparticles Suppress Fibronectinmediated

Silica Nanoparticles Suppress Fibronectin-Mediated Adhesion and Migration in Normal Human Keratinocytes

Signaling Pathways Regulated by Silica Nanoparticles

Signaling Pathways Regulated By Silica Nanoparticles

Mar 05, 2021 Silica nanoparticles are frequently utilized for biomedical purposes including drug delivery, gene therapies, vaccine design, implants, dental fillers, and imaging studies for cancer cases 3,4. In addition, silica nanoparticles are also used in commercial cosmetic products.

Silica nanoparticlesmediated stable genetic

Silica Nanoparticlesmediated Stable Genetic

Oct 20, 2015 Nanoparticles as gene carriers become popular in the mammalian cells, whereas the application of them in plant cells is still very limited. Herein lies a r Silica nanoparticles-mediated stable genetic transformation in Nicotiana tabacum SpringerLink

Chitosanmediated formation of biomimetic silica

Chitosanmediated Formation Of Biomimetic Silica

1. J Biosci Bioeng. 2014 Nov118(5)575-82. doi 10.1016/j.jbiosc.2014.05.003. Epub 2014 Jun 7. Chitosan-mediated formation of biomimetic silica nanoparticles an effective method for manganese peroxidase immobilization and stabilization.

Solgel mediated synthesis of silica nanoparticle from

Solgel Mediated Synthesis Of Silica Nanoparticle From

Feb 15, 2019 Sol-gel mediated synthesis of silica nanoparticle from Bambusa vulgaris leaves and its environmental applications kinetics and isotherms studies. Kaliannan Durairaj 1, Palaninaicker Senthilkumar 1, Palanivel Velmurugan 2, Kavitha Dhamodaran 3, Krishna Kadirvelu 4

Mesoporous Silica NanoparticleMediated Intracellular Cre

Mesoporous Silica Nanoparticlemediated Intracellular Cre

Dec 27, 2013 In this work, we explore direct protein delivery to plant cells using mesoporous silica nanoparticles (MSNs) as carriers to deliver Cre recombinase protein into maize (Zea mays) cells. Cre protein was loaded inside the pores of gold-plated MSN s, and these particles were delivered by the biolistic method to plant cells harboring loxP sites ...

Laccasemediated formation of mesoporous silica

Laccasemediated Formation Of Mesoporous Silica

Sep 09, 2016 In this work, we designed a new hybrid nanogel with redox responsive polymer gel shells and mesoporous silica nanoparticles (MSNs) cores via laccase-mediated radical polymerization. The successful coating of the responsive gel shells on the MSNs was confirmed by the morphology and increased diameters of the particles as determined by transmission electron microscopy (TEM) and

Membrane Fusion Mediated Intracellular Delivery of

Membrane Fusion Mediated Intracellular Delivery Of

Jun 19, 2017 Membrane Fusion Mediated Intracellular Delivery of Lipid Bilayer Coated Mesoporous Silica Nanoparticles Jian Yang, Jing Tu, Gerda E. M. Lamers, Ren C. L. Olsthoorn, and Alexander Kros* DOI 10.1002/adhm.201700759 molecular weight biomole cules like pro - teins.25 As a result, most studies show only low loading capacities and since the

A novel simple and stable mesoporous silica nanoparticle

A Novel Simple And Stable Mesoporous Silica Nanoparticle

Aug 03, 2020 Recombinant pDNA and molecular analysis of the mesoporous silica nanoparticle-mediated putative transgenic tomato plants. a Construction of the pPZP122MPIcryIAb.LB left border, P nopaline synthase promoter, GmR gentamicin resistance, MPI Maize Proteinase Inhibitor promoter, PEPC In 9 Intron 9 of the maize-phosphoenolpyruvate carboxylase gene, T nopaline terminator, RB

Mesoporous silica nanoparticles with lactosemediated

Mesoporous Silica Nanoparticles With Lactosemediated

Aug 21, 2017 Mesoporous silica nanoparticles with lactose-mediated targeting effect to deliver platinum(iv) prodrug for liver cancer therapy Zigui Wang , ab Peng Wu , c Zhilong He , d Hongyan He , a Weifeng Rong , e Jizhen Li ,* c Dongfang Zhou * a and Yubin Huang a

Cellular Fate of a Modular DNA Delivery System

Cellular Fate Of A Modular Dna Delivery System

Jan 26, 2005 Cellular Fate of a Modular DNA Delivery System Mediated by Silica Nanoparticles Richard A. Gemeinhart,* Dan Luo, and W. Mark Saltzman School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, New York 14850-5201

Amorphous silica nanoparticles accelerated atherosclerotic

Amorphous Silica Nanoparticles Accelerated Atherosclerotic

Oct 02, 2020 The biosafety concern of silica nanoparticles (SiNPs) is rapidly expanding alongside with its mass production and extensive applications. The cardiovascular effects of SiNPs exposure have been gradually confirmed, however, the interaction between SiNPs exposure and atherosclerosis, and the underlying mechanisms still remain unknown. Thereby, this study aimed to explore the effects of

Optimization of Nanoparticles for Smart Drug Delivery A

Optimization Of Nanoparticles For Smart Drug Delivery A

Silica nanoparticles are also used in the field of oral vaccine delivery. Wu et al. decided on bovine serum albumin (BSA) as a protein antigen model to reveal the characteristics of mesoporous silica nanoparticles coated with chitosan. The encapsulation efficiency and drug loading were 25.34 0.76 and 20.21 0.48%, respectively.

DNA Vaccine Mediated by RambutanLike Mesoporous

Dna Vaccine Mediated By Rambutanlike Mesoporous

conditions, these silica nanoparticles were dispersed into simulated body fluids (SBF) at 1 mg mL-1 and shaken at 37 C for 7 days. Photography as shown in Figure S2a indicates the degradation of the silica particles over the 7 days of incubation. The milky nanoparticle suspension became semi-

Mesoporous silica nanoparticles in target drug delivery

Mesoporous Silica Nanoparticles In Target Drug Delivery

Cellular uptake of mesoporous silica nanoparticles. Silica based material nanoparticles uptake by cell produce no detectable toxic effects. The mechanism of cellular uptake appears to be mediated by an active endocytosis pathway as MSNs endocytosis is inhibited by a decrease in temperature to 4C that is incubation with metabolic inhibitors.

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